Article

Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation

2018-05-10

Abstract excerpt

<h4>ABSTRACT</h4> In the presence of aggregation-prone proteins, the cytosol and endoplasmic reticulum (ER) undergo a dramatic shift in their respective redox status, with the cytosol becoming more oxidized and the ER more reducing. However, whether and how changes in the cellular redox status may affect protein aggregation is unknown. Here, we show that C. elegans mutants lacking glutathione reductase gsr-1 ge...

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Literature Corpus work: e0edb979-8a9d-5316-ab21-09b637209786
DOI: 10.1101/309849

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