Article
A Genetic Analysis of the Caenorhabditis elegans Detoxification Response.
Genetics - 1 Jun 2017
Fukushige Tetsunari, Smith Harold E, Miwa Johji, Krause Michael W, Hanover John A
Abstract excerpt
Oxidative damage contributes to human diseases of aging including diabetes, cancer, and cardiovascular disorders. Reactive oxygen species resulting from xenobiotic and endogenous metabolites are sensed by a poorly understood process, triggering a cascade of regulatory factors and leading to the activation of the transcription factor Nrf2 (Nuclear factor-erythroid-related factor 2, SKN-1 in Caenorhabditis...
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