Back to search

Article

Crosstalk in oxygen homeostasis networks: SKN-1/NRF inhibits the HIF-1 hypoxia-inducible factor in <i>Caenorhabditis elegans</i>

2021-03-12

Abstract excerpt

During development, homeostasis, and disease, organisms must balance responses that allow adaptation to low oxygen (hypoxia) with those that protect cells from oxidative stress. The evolutionarily conserved hypoxia-inducible factors are central to these processes, as they orchestrate transcriptional responses to oxygen deprivation. Here, we employ genetic strategies in C. elegans to identify stress-responsive gen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
77900758-3346-5d48-b602-144b843625ca
DOI
10.1101/2021.03.12.435071
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Crosstalk in oxygen homeostasis networks: SKN-1/NRF inhibits the HIF-1 hypoxia-inducible factor in <i>Caenorhabditis elegans</i>DOI 10.1101/2021.03.12.435071
The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans.Semantic proximity
The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.Semantic proximity
Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.Semantic proximity
Whole genome profiling of short-term hypoxia induced genes and identification of HIF-1 binding sites provide insights into HIF-1 function in <i>Caenorhabditis elegans</i>Semantic proximity
<i>C. elegans</i> RHY-1 and CYSL-1 act independently of HIF-1 to promote survival in hydrogen sulfideSemantic proximity
Genetic analysis of hypoxia signaling and response in C elegans.Semantic proximity
Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.Semantic proximity
Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1.Semantic proximity
Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans.Semantic proximity
A HIF-independent mediator of transcriptional responses to oxygen deprivation in Caenorhabditis elegans.Semantic proximity
Krüppel-like factor 1 acts upstream of the SKN-1/Nrf transcription factors to modulate oxidative stress, lipid homeostasis and longevitySemantic proximity
Hypoxia-reoxygenation Extends the Lifespan of Caenorhabditis elegans via SKN-1- and DAF-16A-Dependent Stress HormesisSemantic proximity
Select a neighboring publication to make it the new centre.