Article

Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSCs to microglia

2022-08-03

Abstract excerpt

There is increasing genetic evidence for the role of microglia in neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and motor neuron disease. Therefore, there is a need to generate authentic in vitro models to study human microglial physiology. Various methods have been developed using human induced Pluripotent Stem Cells (iPSC) to generate microglia, however, systematic approaches to identify which...

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Literature Corpus work: 540354be-f435-54b3-9d7f-c1bbab6e74a8
DOI: 10.1101/2022.08.02.502447

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