Article

Systematic comparison of culture media uncovers phenotypic shift of human microglia defined by reduced reliance to CSF1R signaling

2022-07-14

Abstract excerpt

Efforts to understand microglia function in health and diseases have been hindered by the lack of culture models that recapitulate in situ cellular properties. In recent years, the use of serum-free media with brain-derived growth factors (CSF1R ligands and TGF-β1/2) have been favored for the maintenance of rodent microglia as they promote morphological features observed in situ . Here we study the functional an...

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Literature Corpus work: 8f4e34b8-6f9b-50d4-aa7d-6e9001052b0c
DOI: 10.1101/2022.07.14.500101

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