Article

FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinoma

2021-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Changes in cellular identity (also known as histologic transformation or lineage plasticity) can drive malignant progression and resistance to therapy in multiple types of cancer, including lung adenocarcinoma (LUAD). The lineage specifying transcription factors FoxA1 and FoxA2 (FoxA1/2) regulate identity in NKX2-1/TTF1-negative LUAD. However, their role in NKX2-1-positive LUAD has not been syst...

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Literature Corpus work: 53cb63c9-0538-53ea-98de-878bb0fbe6cd
DOI: 10.1101/2021.06.29.450247

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