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Article

ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer

5 Aug 2021

Abstract excerpt

Lineage-defining transcription factors (LTFs) play key roles in small-cell lung cancer (SCLC) pathophysiology. Delineating the LTF-regulated genes operative in SCLC could provide a road map to identify SCLC dependencies. We integrated chromatin landscape and transcriptome analyses of patient-derived SCLC preclinical models to identify super-enhancers (SEs) and their associated genes in the ASCL1-, NEUROD1-, and...

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PMID: 34466783
DOI: 10.1016/j.isci.2021.102953

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