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Transcriptional Circuitry of NKX2-1 and SOX1 Defines an Unrecognized Lineage Subtype of Small-Cell Lung Cancer

18 Jul 2022

Abstract excerpt

Abstract Rationale The current molecular classification of small-cell lung cancer (SCLC) on the basis of the expression of four lineage transcription factors still leaves its major subtype SCLC-A as a heterogeneous group, necessitating more precise characterization of lineage subclasses. Objectives To refine the current SCLC classification with epigenomic profiles and to identify features of the redefined SCLC...

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PMID: 35848993
DOI: 10.1164/rccm.202110-2358oc

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