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Article

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma.

eLife - 6 Apr 2021

Zewdu Rediet, Mehrabad Elnaz Mirzaei, Ingram Kelley, Fang Pengshu, Gillis Katherine L, Camolotto Soledad A, Orstad Grace, Jones Alex, Mendoza Michelle C, Spike Benjamin T, Snyder Eric L

Abstract excerpt

Cancer cells undergo lineage switching during natural progression and in response to therapy. NKX2-1 loss in human and murine lung adenocarcinoma leads to invasive mucinous adenocarcinoma (IMA), a lung cancer subtype that exhibits gastric differentiation and harbors a distinct spectrum of driver oncogenes. In murine BRAFV600E-driven lung adenocarcinoma, NKX2-1 is required for early tumorigenesis, but dispensable...

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Identifiers

PMID: 33821796
DOI: 10.7554/eLife.66788
PMCID: PMC8102067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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