Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.

Nature communications - 4 May 2021

Little Danielle R, Lynch Anne M, Yan Yun, Akiyama Haruhiko, Kimura Shioko, Chen Jichao

Abstract excerpt

Differential transcription of identical DNA sequences leads to distinct tissue lineages and then multiple cell types within a lineage, an epigenetic process central to progenitor and stem cell biology. The associated genome-wide changes, especially in native tissues, remain insufficiently understood, and are hereby addressed in the mouse lung, where the same lineage transcription factor NKX2-1 promotes the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Alveolar Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Immunoprecipitation

Share to Chromatin Immunoprecipitation Sequencing

Share to Gene Knock-In Techniques

Share to RNA-Seq

Share to Thyroid Nuclear Factor 1

Share to YAP-Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33947861
DOI: 10.1038/s41467-021-22817-6
PMCID: PMC8096971

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.PMID 33947861Read ↗

Genome-Wide Analyses of Nkx2-1 Binding to Transcriptional Target Genes Uncover Novel Regulatory Patterns Conserved in Lung Development and TumorsSemantic proximity Read ↗

FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinomaSemantic proximity Read ↗

The Lineage-Specific Transcription Factor CDX2 Navigates Dynamic Chromatin to Control Distinct Stages of Intestine DevelopmentSemantic proximity Read ↗

Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identitySemantic proximity Read ↗

Transcriptional Circuitry of NKX2-1 and SOX1 Defines an Unrecognized Lineage Subtype of Small-Cell Lung CancerSemantic proximity Read ↗

Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory diseaseSemantic proximity Read ↗

Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identitySemantic proximity Read ↗

Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.Semantic proximity Read ↗

KrasG12D and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lungSemantic proximity Read ↗

Region-specific molecular regulatory programs define epithelial identity, progenitor states, and mucus homeostasis in human distal airwaysSemantic proximity Read ↗

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancersSemantic proximity Read ↗

Lineage transcription factors co-regulate subtype-specific genes providing a roadmap for systematic identification of small cell lung cancer vulnerabilitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.