Article

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

2023-10-01

Abstract excerpt

Lung adenocarcinoma (LUAD), commonly driven by KRAS mutations, is responsible for 7% of all cancer mortality. The first allele-specific KRAS inhibitors were recently approved in LUAD, but clinical benefit is limited by intrinsic and acquired resistance. LUAD predominantly arises from alveolar type 2 (AT2) cells, which function as facultative alveolar stem cells by self-renewing and replacing alveolar type 1 (AT1)...

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Literature Corpus work: f6d9c349-4360-53bd-af36-3f26d07df383
DOI: 10.1101/2023.09.29.560194

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