Article

Lineage identity governs oncogene dependence in murine NSCLC models of KRAS inhibitor resistance

2025-07-24

Abstract excerpt

<title>Abstract</title> <p>Primary and acquired resistance to targeted therapy represent significant challenges to durable treatment responses in cancer. In lung cancer and other cancer types, allele- specific and pan-KRAS inhibitors offer new promise, but these are hampered by incomplete responses as well as genetic and non-genetic mechanisms of acquired resistance. To model these mechanisms, we treat geneticall...

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Literature Corpus work: 03cb965d-005a-51c9-9bef-8a6e82f9e82d
DOI: 10.21203/rs.3.rs-7058952/v1

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