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LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer

28 Feb 2022

Abstract excerpt

LKB1 is among the most frequently altered tumor suppressors in lung adenocarcinoma. Inactivation of Lkb1 accelerates the growth and progression of oncogenic KRAS-driven lung tumors in mouse models. However, the molecular mechanisms by which LKB1 constrains lung tumorigenesis and whether the cancer state that stems from Lkb1 deficiency can be reverted remains unknown. To identify the processes governed by LKB1 in...

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PMID: 35228570
DOI: 10.1038/s41467-022-28619-8

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