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KrasG12D and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung

12 Nov 2012

Abstract excerpt

Mucinous adenocarcinoma of the lung is a subtype of highly invasive pulmonary tumors and is associated with decreased or absent expression of the transcription factor NK2 homeobox 1 (NKX2-1; also known as TTF-1). Here, we show that haploinsufficiency of Nkx2-1 in combination with oncogenic Kras(G12D), but not with oncogenic EGFR(L858R), caused pulmonary tumors in transgenic mice that were phenotypically similar...

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PMID: 23143308
DOI: 10.1172/jci64048

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