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Article

Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity.

Developmental cell - 7 Feb 2022

Kadur Lakshminarasimha Murthy Preetish, Xi Rui, Arguijo Diana, Everitt Jeffrey I, Kocak Dewran D, Kobayashi Yoshihiko, Bozec Aline, Vicent Silvestre, Ding Shengli, Crawford Gregory E, Hsu David, Tata Purushothama Rao, Reddy Timothy, Shen Xiling

Abstract excerpt

Oncogenic Kras induces a hyper-proliferative state that permits cells to progress to neoplasms in diverse epithelial tissues. Depending on the cell of origin, this also involves lineage transformation. Although a multitude of downstream factors have been implicated in these processes, the precise chronology of molecular events controlling them remains elusive. Using mouse models, primary human tissues, and cell...

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Identifiers

PMID: 35134344
DOI: 10.1016/j.devcel.2022.01.006
PMCID: PMC8938988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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