Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Persistent lineage plasticity driving lung cancer development and progression

1 Aug 2025

Abstract excerpt

BACKGROUND: Lung cancer, a leading cause of cancer death, displays profound histologic and molecular heterogeneity across adenocarcinoma, squamous, and small-cell types. Clinically, tumours can shift between these states, reflecting lineage plasticity-the reprogramming of differentiated cells to alternate identities. Pre-existing genomic/epigenomic diversity and microenvironmental cues supply the substrates and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40847555
DOI: 10.1002/ctm2.70458

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Persistent lineage plasticity driving lung cancer development and progressionPMID 40847555Read ↗

Molecular Landscape and Therapeutic Strategies of Lung Cancer Lineage PlasticitySemantic proximity Read ↗

Lineage Plasticity and Histologic Transformation in EGFR-TKI Resistant Lung Cancer.Semantic proximity Read ↗

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinomaSemantic proximity Read ↗

Lung Adenocarcinoma Tumor Origin: A Guide for Personalized MedicineSemantic proximity Read ↗

Club cells employ regeneration mechanisms during lung tumorigenesisSemantic proximity Read ↗

Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiationSemantic proximity Read ↗

An atlas of epithelial cell states and plasticity in lung adenocarcinomaSemantic proximity Read ↗

The Transcriptional and Epigenetic Landscape of Cancer Cell Lineage PlasticitySemantic proximity Read ↗

Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformationSemantic proximity Read ↗

Aggressive early-stage lung adenocarcinoma is characterized by epithelial cell plasticity with acquirement of stem-like traits and immune evasion phenotype.Semantic proximity Read ↗

Data-driven Understanding On Cancer Lineage Plasticity: Examples and ChancesSemantic proximity Read ↗

KLF4 promotes a KRT13+ hillock-like state in lung squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.