Article

Analysis of <i>DNM3</i> and <i>VAMP4</i> as genetic modifiers of <i>LRRK2</i> Parkinson’s disease

2019-06-28

Abstract excerpt

<h4>Objective</h4> To assess genetic modifiers of Parkinson’s disease (PD) age at onset (AAO) penetrance in individuals carrying common and rare LRRK2 risk alleles <h4>Methods</h4> We analysed reported genetic modifier DNM3 rs2421947 in 724 LRRK2 p.G2019S heterozygotes using linear regression of AAO. We meta-analysed our data with previously published data (n=754). VAMP4 is in close proximity to DNM3 and i...

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Literature Corpus work: 53aba51d-056d-5aec-970d-13fc5ea3afb1
DOI: 10.1101/686550

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