Article

Penetrance of Parkinson’s disease in <i>LRRK2</i> p.G2019S carriers is modified by a polygenic risk score

2019-08-16

Abstract excerpt

<h4>Background</h4> While the LRRK2 p.G2019S mutation has been demonstrated to be a strong risk factor for Parkinson’s Disease (PD), factors that contribute to penetrance among carriers, other than aging, have not been well identified. <h4>Objectives</h4> To evaluate whether a cumulative genetic risk identified in the recent genome-wide study is associated with penetrance of PD among p.G2019S mutation carriers....

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Literature Corpus work: 52aae8b3-7d15-52f2-bbab-84a53e69bd2d
DOI: 10.1101/738260

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