Article

Analysis of LRRK2 G2019S carriers in the All of Us research program database

2026-08-03

Abstract excerpt

<title>Abstract</title> <p> The <italic>LRRK2</italic> G2019S variant is a major genetic cause of Parkinson’s disease (PD), yet its lifetime penetrance remains uncertain. We used the <italic>All of Us</italic> (AoU) database to investigate G2019S penetrance and modifiers of disease manifestation. We analyzed <italic>LRRK2</italic> G2019S carriers from the AoU v8 whole-genome sequencing dataset and stratifi...

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Literature Corpus work: 5a218366-0772-55d5-ae72-15dd9fae8658
DOI: 10.21203/rs.3.rs-10550988/v1

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