Article

Monogenic Parkinson’s Disease and the Impact of<i>APOE</i>E4: A Case-Control Study

2024-11-16

Abstract excerpt

<h4>Importance</h4> The lack of information on progression, phenoconversion, and risk of dementia in a large genotyped sample impedes reliable enrichment for early interventional trials in Parkinson’s disease (PD). <h4>Objective</h4> To investigate PD penetrance, risk, motor/non-motor phenotypes, and APOE allele effects in LRRK2 G2019S and GBA N370S carriers. <h4>Design</h4> Observational longitudinal case-control...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e08265a5-c896-5d85-ae0f-0d5f02651ff3
DOI: 10.1101/2024.11.15.24317402

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Monogenic Parkinson’s Disease and the Impact of<i>APOE</i>E4: A Case-Control StudyDOI 10.1101/2024.11.15.24317402Read

Genetic Analysis and Natural History of Parkinson’s Disease Due to the LRRK2 G2019S VariantSemantic proximity Read

Parkinson’s Disease: From Gene–Environment Risk to Precision TherapySemantic proximity Read

Parkinson's Disease: From Gene-Environment Risk to Precision Therapy.Semantic proximity Read

Novel Parkinson’s Disease Genetic Risk Factors Within and Across European PopulationsSemantic proximity Read

Estimated genetics prevalence of early-onset Parkinson’s disease caused by<i>PRKN</i>mutationsSemantic proximity Read

<p class="MDPI13authornamesori1" style="margin-bottom: 12.0pt; mso-line-height-alt: 14.0pt;">Genetic Associations of Parkinson’s Disease Clinical, Pathological, and Data-driven SubtypesSemantic proximity Read

Penetrance of Parkinson’s disease in <i>LRRK2</i> p.G2019S carriers is modified by a polygenic risk scoreSemantic proximity Read

An update on the monogenic causes of Parkinson's disease: Impact on patient stratification and personalised medicine.Semantic proximity Read

Genome-wide association study of Parkinson’s disease progression biomarkers in 12 longitudinal patients’ cohortsSemantic proximity Read

Genetic analysis and natural history of Parkinson's disease due to the LRRK2 G2019S variant.Semantic proximity Read

Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance.Semantic proximity Read

Expanding Parkinson’s disease genetics: novel risk loci, genomic context, causal insights and heritable riskSemantic proximity Read