Article

<i>LRRK2</i> p.G2385R and p.R1628P Variants in a Multi-Ethnic Asian Parkinson’s Cohort: Epidemiology and Clinical Insights

2025-08-08

Abstract excerpt

<h4>ABSTRACT</h4> The frequency and clinical impact of LRRK2 p.G2385R and p.R1628P risk variants in Parkinson’s disease (PD) remain uncertain, particularly across different Asian populations. We genotyped 3,058 multi-ethnic Malaysian PD patients, performed detailed phenotyping in 185, and analyzed disease progression in 635 using longitudinal Clinical Impression of Severity Index for PD scores. p.G2385R was large...

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Literature Corpus work: 251953c5-662d-5e7d-9ce9-6b5d50b20d12
DOI: 10.1101/2025.08.06.25332985

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