Article

Genome-wide association studies of LRRK2 modifiers of Parkinson's disease

2020-12-16

Abstract excerpt

<h4>Objective: </h4> The aim of this study was to search for genes/variants that modify the effect of LRRK2 mutations in terms of penetrance and age-at-onset of Parkinson's disease. Methods: We performed the first genome-wide association study of penetrance and age-at-onset of Parkinson's disease in LRRK2 mutation carriers (776 cases and 1,103 non-cases at their last evaluation). Cox proportional hazard models and...

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Literature Corpus work: 38597118-1348-5cad-a055-b6275db34468
DOI: 10.1101/2020.12.14.20224378

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