Article

The <i>LRRK2</i> R1441G+M1646T haplotype is associated with slower motor symptom progression in Parkinson's disease

2026-08-31

Abstract excerpt

<h4>Background: </h4> Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic risk factor for Parkinson's disease (PD). G2019S, the most common pathogenic variant, has been linked to milder motor symptoms, but the effects of other LRRK2 variants on disease trajectory remain incompletely characterized. R1441G, the second most common pathogenic variant, co-occurs with the PD risk variant M1646T...

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Literature Corpus work: 405a1019-f0b0-5659-9800-16100481abc9
DOI: 10.64898/2026.08.26.26361428

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