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The <i>LRRK2</i> p.A419V variant associates with risk of Parkinson’s disease in the East Asian population and an evaluation on age of onset

2025-09-02

Abstract excerpt

Common and rare variants in LRRK2 influence Parkinson’s disease (PD) risk across diverse populations. We investigated the p.A419V variant across multiple ancestry cohorts comprising over 200,000 individuals. In cases of East Asian ancestry, the variant was significantly associated with increased risk (OR = 2.9; 95% CI: 1.66–5.10; p = 0.0002), It lies on rare EAS haplotypes, and was not in linkage disequilibrium wi...

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Literature Corpus work
605f4036-eac7-533b-a82e-7fad9c453254
DOI
10.1101/2025.08.28.25333987
Open publication

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The <i>LRRK2</i> p.A419V variant associates with risk of Parkinson’s disease in the East Asian population and an evaluation on age of onsetDOI 10.1101/2025.08.28.25333987
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