Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease.

doi:10.1016/j.neurobiolaging.2020.07.002

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Article

Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease.

Neurobiology of aging - 1 Jan 2021

Brown Emmeline E, Blauwendraat Cornelis, Trinh Joanne, Rizig Mie, Nalls Mike A, Leveille Etienne, Ruskey Jennifer A, Jonvik Hallgeir, Tan Manuela M X, Bandres-Ciga Sara, Hassin-Baer Sharon, Brockmann Kathrin, Infante Jon, Tolosa Eduardo, Ezquerra Mario, Ben Romdhan Sawssan, Benmahdjoub Mustapha, Arezki Mohamed, Mhiri Chokri, Hardy John, Singleton Andrew B, Alcalay Roy N, Gasser Thomas, Grosset Donald G, Williams Nigel M, Pittman Alan, Gan-Or Ziv, Fernandez-Santiago Ruben, Brice Alexis, Lesage Suzanne, Farrer Matthew, Wood Nicholas, Morris Huw R

Abstract excerpt

The LRRK2 gene has rare (p.G2019S) and common risk variants for Parkinson's disease (PD). DNM3 has previously been reported as a genetic modifier of the age at onset in PD patients carrying the LRRK2 p.G2019S mutation. We analyzed this effect in a new cohort of LRRK2 p.G2019S heterozygotes (n = 724) and meta-analyzed our data with previously published data (n = 754). VAMP4 is in close proximity to DNM3, and was...

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PMID: 32873436
DOI: 10.1016/j.neurobiolaging.2020.07.002
PMCID: PMC7762821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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