Article

Evaluating Individual Level Performance of Polygenic Risk Scores Using Early Onset High Genetic Risk Coronary Artery Disease as a Benchmark

2026-04-18

Abstract excerpt

Polygenic risk scores (PRSs) are typically validated using population-level metrics, masking variability in individual-level risk prediction and hindering clinical translation. To address this, we introduced a novel framework using a “benchmark” cohort (N=1184) of “unexpected coronary artery disease (CAD)”: early-onset patients (<55 years) with a clinical profile—low 10-year risk, no diabetes or severe hypercholes...

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Literature Corpus work: 537f4a27-6b4e-5887-8a37-784d054150aa
DOI: 10.64898/2026.04.16.26350801

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