Article
Polygenic risk score validation using Korean genomes of 265 early-onset acute myocardial infarction patients and 636 healthy controls.
PloS one - 1 Jan 2021
Bhak Youngjune, Jeon Yeonsu, Jeon Sungwon, Yoon Changhan, Kim Min, Blazyte Asta, Kim Yeonkyung, Kang Younghui, Kim Changjae, Lee Sang Yeub, Bae Jang-Whan, Kim Weon, Kim Yeo Jin, Shim Jungae, Kim Nayeong, Chun Sung, Kim Byoung-Chul, Kim Byung Chul, Lee Semin, Bhak Jong, Shin Eun-Seok
Abstract excerpt
BACKGROUND: The polygenic risk score (PRS) developed for coronary artery disease (CAD) is known to be effective for classifying patients with CAD and predicting subsequent events. However, the PRS was developed mainly based on the analysis of Caucasian genomes and has not been validated for East Asians. We aimed to evaluate the PRS in the genomes of Korean early-onset AMI patients (n = 265, age ≤50 years)...
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