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Article

Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores.

JAMA - 7 Jan 2025

Abramowitz Sarah A, Boulier Kristin, Keat Karl, Cardone Katie M, Shivakumar Manu, DePaolo John, Judy Renae, Bermudez Francisca, Mimouni Nour, Neylan Christopher, Kim Dokyoon, Rader Daniel J, Ritchie Marylyn D, Voight Benjamin F, Pasaniuc Bogdan, Levin Michael G, Damrauer Scott M

Abstract excerpt

Importance: Polygenic risk scores (PRSs) for coronary heart disease (CHD) are a growing clinical and commercial reality. Whether existing scores provide similar individual-level assessments of disease susceptibility remains incompletely characterized. Objective: To characterize the individual-level agreement of CHD PRSs that perform similarly at the population level. Design, Setting, and Participants:...

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Identifiers

PMID: 39549270
DOI: 10.1001/jama.2024.23784
PMCID: PMC11569413

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