Article

Optogenetic dissection of mitotic spindle positioning in vivo

2018-05-14

Abstract excerpt

<h4>ABSTRACT</h4> The position of the mitotic spindle determines the plane of cell cleavage, and thereby the location, size, and content of daughter cells. Spindle positioning is driven by dynein-mediated pulling forces exerted on astral microtubules. This process requires an evolutionarily conserved complex of Gα-GDP, GPR-1/2 Pins/LGN , and LIN-5 Mud/NuMA proteins. It remains unknown whether this complex merel...

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Literature Corpus work: 53378599-9276-572e-a955-c3b3948f499e
DOI: 10.1101/319772

Open publication

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