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Article

Optogenetic dissection of mitotic spindle positioning in vivo.

eLife - 15 Aug 2018

Fielmich Lars-Eric, Schmidt Ruben, Dickinson Daniel J, Goldstein Bob, Akhmanova Anna, van den Heuvel Sander

Abstract excerpt

The position of the mitotic spindle determines the plane of cell cleavage, and thereby daughter cell location, size, and content. Spindle positioning is driven by dynein-mediated pulling forces exerted on astral microtubules, which requires an evolutionarily conserved complex of Gα∙GDP, GPR-1/2Pins/LGN, and LIN-5Mud/NuMA proteins. To examine individual functions of the complex components, we developed a genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30109984
DOI: 10.7554/eLife.38198
PMCID: PMC6214656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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