Article
Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II.
The Journal of cell biology - 24 Sept 2007
Goulding Morgan B, Canman Julie C, Senning Eric N, Marcus Andrew H, Bowerman Bruce
Abstract excerpt
Mitotic spindle positioning in the Caenorhabditis elegans zygote involves microtubule-dependent pulling forces applied to centrosomes. In this study, we investigate the role of actomyosin in centration, the movement of the nucleus-centrosome complex (NCC) to the cell center. We find that the rate of wild-type centration depends equally on the nonmuscle myosin II NMY-2 and the Galpha proteins GOA-1/GPA-16. In...
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