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Article

Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos.

Science (New York, N.Y.) - 20 Jun 2003

Colombo Kelly, Grill Stephan W, Kimple Randall J, Willard Francis S, Siderovski David P, Gönczy Pierre

Abstract excerpt

Asymmetric divisions are crucial for generating cell diversity; they rely on coupling between polarity cues and spindle positioning, but how this coupling is achieved is poorly understood. In one-cell stage Caenorhabditis elegans embryos, polarity cues set by the PAR proteins mediate asymmetric spindle positioning by governing an imbalance of net pulling forces acting on spindle poles. We found that the...

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PMID: 12750478
DOI: 10.1126/science.1084146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos.PMID 12750478Read ↗

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