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The spatiotemporal distribution of LIN-5/NuMA regulates spindle orientation in the C. elegans germ line

1 Feb 2025

Abstract excerpt

Mitotic spindle orientation contributes to tissue organization and shape by setting the cell division plane. How spindle orientation is coupled to diverse tissue architectures is incompletely understood. The C. elegans gonad is a tube-shaped organ with germ cells forming a circumferential monolayer around a common cytoplasmic lumen. How this organization is maintained during development is unclear, as germ cells...

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PMID: 39946234
DOI: 10.1016/j.celrep.2025.115296

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