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Article

aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.

Nature cell biology - 21 Aug 2011

Galli Matilde, Muñoz Javier, Portegijs Vincent, Boxem Mike, Grill Stephan W, Heck Albert J R, van den Heuvel Sander

Abstract excerpt

The position of the mitotic spindle controls the plane of cell cleavage and determines whether polarized cells divide symmetrically or asymmetrically. In animals, an evolutionarily conserved pathway of LIN-5 (homologues: Mud and NuMA), GPR-1/2 (homologues: Pins, LGN, AGS-3) and Gα mediates spindle positioning, and acts downstream of the conserved PAR-3-PAR-6-aPKC polarity complex. However, molecular interactions...

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Identifiers

PMID: 21857670
DOI: 10.1038/ncb2315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.PMID 21857670Read ↗

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