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Article

Two populations of cytoplasmic dynein contribute to spindle positioning in C. elegans embryos.

The Journal of cell biology - 4 Sept 2017

Schmidt Ruben, Fielmich Lars-Eric, Grigoriev Ilya, Katrukha Eugene A, Akhmanova Anna, van den Heuvel Sander

Abstract excerpt

The position of the mitotic spindle is tightly controlled in animal cells as it determines the plane and orientation of cell division. Contacts between cytoplasmic dynein and astral microtubules (MTs) at the cell cortex generate pulling forces that position the spindle. An evolutionarily conserved Gα-GPR-1/2Pins/LGN-LIN-5Mud/NuMA cortical complex interacts with dynein and is required for pulling force generation,...

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Identifiers

PMID: 28739679
DOI: 10.1083/jcb.201607038
PMCID: PMC5584144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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