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Article

LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.

Development (Cambridge, England) - 1 Dec 2003

Tsou Meng-Fu Bryan, Hayashi Adam, Rose Lesilee S

Abstract excerpt

G-protein signaling plays important roles in asymmetric cell division. In C. elegans embryos, homologs of receptor-independent G protein activators, GPR-1 and GPR-2 (GPR-1/2), function together with Galpha (GOA-1 and GPA-16) to generate asymmetric spindle pole elongation during divisions in the P lineage. Although Galpha is uniformly localized at the cell cortex, the cortical localization of GPR-1/2 is asymmetric...

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Source

Identifiers

PMID: 14534135
DOI: 10.1242/dev.00790

Genes

SRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.PMID 14534135Read ↗

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RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans.Semantic proximity Read ↗

PAR-dependent and geometry-dependent mechanisms of spindle positioning.Semantic proximity Read ↗

Optogenetic dissection of mitotic spindle positioning in vivoSemantic proximity Read ↗

The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo.Semantic proximity Read ↗

Embryonic handedness choice in C. elegans involves the Galpha protein GPA-16.Semantic proximity Read ↗

The 14-3-3 protein PAR-5 regulates the asymmetric localization of the LET-99 spindle positioning protein.Semantic proximity Read ↗

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.Semantic proximity Read ↗

Optogenetic dissection of mitotic spindle positioning in vivo.Semantic proximity Read ↗

The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Semantic proximity Read ↗

aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.Semantic proximity Read ↗

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