Article

The tumor suppressor APC is an attenuator of spindle-pulling forces during <i>C. elegans</i> asymmetric cell division

2017-06-30

Abstract excerpt

The adenomatous polyposis coli (APC) tumor suppressor has dual functions in Wnt/ß-catenin signaling and accurate chromosome segregation, and is frequently mutated in colorectal cancers. Although APC contributes to proper cell division, the underlying mechanisms remain poorly understood. Here we show that C. elegans APR-1/APC is an attenuator of the pulling forces acting on the mitotic spindle. During asymmetric c...

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Literature Corpus work: b9bad0ed-94ef-50b4-9808-1f2876d2129b
DOI: 10.1101/157404

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