Article

PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor

2024-12-04

Abstract excerpt

The phosphoinositide 3-kinase (PI3K) pathway is a major regulator of cell and organismal growth. Consequently, hyperactivation of PI3K and its downstream effector kinase, Akt, is observed in many human cancers. PH domain leucine-rich repeat-containing protein phosphatases (PHLPP), two paralogous members of the metal-dependent protein phosphatase family, have been reported as negative regulators of Akt signaling an...

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Literature Corpus work: 53245ac8-1999-5cbb-b8e7-e5364980a447
DOI: 10.1101/2024.12.03.625870

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