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Article

Suppression of survival signalling pathways by the phosphatase PHLPP.

The FEBS journal - 1 Jan 2013

O'Neill Audrey K, Niederst Matthew J, Newton Alexandra C

Abstract excerpt

The recently discovered pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase (PHLPP) family is emerging as a central component in suppressing cell survival pathways. Originally discovered in a rational search for a phosphatase that directly dephosphorylates and inactivates Akt, PHLPP is now known to potently suppress cell survival both by inhibiting proliferative pathways and by promoting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoprotein Phosphatases

Share to Prostatic Neoplasms

Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 22340730
DOI: 10.1111/j.1742-4658.2012.08537.x
PMCID: PMC3770140

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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