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The PTEN–PI3K Axis in Cancer

17 Apr 2019

Abstract excerpt

The PI3K-AKT-mTOR signal transduction pathway regulates a variety of biological processes including cell growth, cell cycle progression and proliferation, cellular metabolism, and cytoskeleton reorganization. Fine-tuning of the phosphatidylinositol 3-kinase (PI3K) pathway signaling output is essential for the maintenance of tissue homeostasis and uncontrolled activation of this cascade leads to a number of human...

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PMID: 30999672
DOI: 10.3390/biom9040153

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