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Article

PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth.

The Journal of biological chemistry - 14 Aug 2020

Kozlov Guennadi, Funato Yosuke, Chen Yu Seby, Zhang Zhidian, Illes Katalin, Miki Hiroaki, Gehring Kalle

Abstract excerpt

Phosphatases of regenerating liver (PRLs) are markers of cancer and promote tumor growth. They have been implicated in a variety of biochemical pathways but the physiologically relevant target of phosphatase activity has eluded 20 years of investigation. Here, we show that PRL3 catalytic activity is not required in a mouse model of metastasis. PRL3 binds and inhibits CNNM4, a membrane protein associated with...

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Identifiers

PMID: 32571875
DOI: 10.1074/jbc.RA120.014464
PMCID: PMC7450121

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