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Article

Protein phosphatase 1 in tumorigenesis: is it worth a closer look?

Biochimica et biophysica acta. Reviews on cancer - 1 Dec 2020

Felgueiras Juliana, Jerónimo Carmen, Fardilha Margarida

Abstract excerpt

Cancer cells take advantage of signaling cascades to meet their requirements for sustained growth and survival. Cell signaling is tightly controlled by reversible protein phosphorylation mechanisms, which require the counterbalanced action of protein kinases and protein phosphatases. Imbalances on this system are associated with cancer development and progression. Protein phosphatase 1 (PP1) is one of the most...

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PMID: 32956763
DOI: 10.1016/j.bbcan.2020.188433

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