Article
Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.
The Journal of biological chemistry - 29 May 2009
Brognard John, Niederst Matthew, Reyes Gloria, Warfel Noel, Newton Alexandra C
Abstract excerpt
PHLPP2 (PH domain leucine-rich repeat protein phosphatase 2) terminates Akt and protein kinase C (PKC) activity by specifically dephosphorylating these kinases at a key regulatory site, the hydrophobic motif (Ser-473 in Akt1). Here we identify a polymorphism that results in an amino acid change from a Leu to Ser at codon 1016 in the phosphatase domain of PHLPP2, which reduces phosphatase activity toward Akt both...
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