Article

The PTEN-PI3K Axis in Cancer

2019-04-10

Abstract excerpt

The PI3K-AKT-mTOR signal transduction pathway regulates a variety of biological processes including cell growth, cell cycle progression and proliferation, cellular metabolism and cytoskeleton reorganization. Fine-tuning of the PI3K pathway signaling output is essential for the maintenance of tissue homeostasis and uncontrolled activation of this cascade leads to a number of human pathologies including cancer. Inac...

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Literature Corpus work: 9c334f05-4f8a-5a28-9d53-a3f46a29c142
DOI: 10.20944/preprints201904.0127.v1

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