Article
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors.
Pharmacology & therapeutics - 1 Nov 2020
Kamada Rui, Kudoh Fuki, Ito Shogo, Tani Itsumi, Janairo Jose Isagani B, Omichinski James G, Sakaguchi Kazuyasu
Abstract excerpt
Protein phosphatases and kinases control multiple cellular events including proliferation, differentiation, and stress responses through regulating reversible protein phosphorylation, the most important post-translational modification. Members of metal-dependent protein phosphatase (PPM) family, also known as PP2C phosphatases, are Ser/Thr phosphatases that bind manganese/magnesium ions (Mn2+/Mg2+) in their...
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