Article

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

2018-10-11

Abstract excerpt

<h4>SUMMARY</h4> PTEN is a tumor suppressor that is often inactivated in cancer and possesses both lipid and protein phosphatase activities. We report the metabolic regulator PDHK1 (pyruvate dehydrogenase kinase1) is a synthetic-essential gene in PTEN-deficient cancer and normal cells. The predominant mechanism of PDHK1 regulation and dependency is the PTEN protein phosphatase dephosphorylates NFκ;B activating pr...

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Literature Corpus work: 6b6cc3ff-8037-51ee-b021-72737d665acc
DOI: 10.1101/441295

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