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Article

Physiological and oncogenic roles of the PRL phosphatases

17 May 2018

Abstract excerpt

The human Phosphatase of Regenerative Liver (PRL) family comprises three members (PRL-1, -2, -3; gene name PTP4A1, PTP4A2, PTP4A3) that are highly expressed in a majority of cancers. This review summarizes our current understanding of PRL biology, including an overview of their evolutionary relationships and the regulatory mechanisms controlling their expression. We provide an updated view on our current...

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PMID: 29770564
DOI: 10.1111/febs.14503

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