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Loss of CFIm activates YAP/TAZ and connects mRNA cleavage and polyadenylation inhibition to BRCAness

2025-10-21

Abstract excerpt

<h4>SUMMARY</h4> The YAP/TAZ transcription program plays a crucial role in development, regeneration, and cancer. CFIm is a master regulator of mRNA alternative polyadenylation (APA). Loss of CFIm function was shown in human cancer but its impact on the gene expression program is not well characterized. Here we report the discovery that loss of CFIm in cancer cells activates YAP/TAZ and promotes therapeutic resis...

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Literature Corpus work
52f4ed10-9038-5c47-975d-305f1914e4d1
DOI
10.1101/2025.10.21.683728
Open publication

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Loss of CFIm activates YAP/TAZ and connects mRNA cleavage and polyadenylation inhibition to BRCAnessDOI 10.1101/2025.10.21.683728
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