Article

Nuclear TARBP2 drives oncogenic dysregulation of RNA splicing and decay

2018-08-17

Abstract excerpt

<h4>SUMMARY</h4> Post-transcriptional regulation of RNA stability is a key step in gene expression control. We describe a regulatory program, mediated by the double-stranded RNA binding protein TARBP2, that controls RNA stability in the nucleus. TARBP2 binding to pre-mRNAs results in increased intron retention, subsequently leading to targeted degradation of TARBP2-bound transcripts. This is mediated by TARBP2 re...

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Literature Corpus work: d4d5162f-b34e-52b1-be36-3e80de34feda
DOI: 10.1101/389213

Open publication

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