Article

A nuclear RNA degradation code for eukaryotic transcriptome surveillance

2024-07-24

Abstract excerpt

<h4>SUMMARY</h4> The RNA exosome plays critical roles in eukaryotic RNA degradation, but it remains unclear how the exosome specifically recognizes its targets. The PAXT connection is an adaptor that recruits the exosome to polyadenylated RNAs in the nucleus, especially transcripts polyadenylated at intronic poly(A) sites. Here we show that PAXT-mediated RNA degradation is induced by the combination of a 5′ splic...

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Literature Corpus work: 66e2e025-07d2-5771-aec0-f0b0d2706a26
DOI: 10.1101/2024.07.23.604837

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